Serum cytokeratin-18 fragment level: A noninvasive biomarker for not only nonalcoholic steatohepatitis, but also alcoholic steatohepatitis
نویسندگان
چکیده
منابع مشابه
Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study.
UNLABELLED Liver biopsy remains the gold standard for diagnosing nonalcoholic steatohepatitis (NASH). We have recently demonstrated that plasma cytokeratin 18 (CK-18) fragment levels correlate with the magnitude of hepatocyte apoptosis and independently predict the presence of NASH. The goal of this study was to validate the use of this biomarker for NASH diagnosis. The study was an ancillary s...
متن کاملSerum cytokeratin 18 fragment level as a noninvasive biomarker for non-alcoholic fatty liver disease.
BACKGROUND AND AIM We evaluated the usefulness of serum cytokeratin 18 fragment (CK18-F) as a noninvasive biomarker in differentiating nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver (NAFL) since the prognosis of the 2 diseases differ. METHODS 116 Japanese patients with nonalcoholic fatty liver disease (NAFLD) proven by liver biopsy were studied. Histological findings were c...
متن کاملSerum cytokeratin-18 in the diagnosis of non-alcoholic steatohepatitis: A meta-analysis.
AIM Identifying patients with non-alcoholic steatohepatitis (NASH), a more aggressive form with a worse prognosis than for simple steatosis, is highly important. Liver biopsy still remains the gold standard for diagnosing NASH, but with limitations. The diagnostic value of serum cytokeratin-18 (CK-18) in predicting NASH is still indefinite. METHODS We selected relevant studies by a literature...
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Alcohol liver disease (ALD) as well as nonalcoholic fatty liver disease (NAFLD) are two of the most common forms of chronic liver disease worldwide and may progress to cirrhosis and end stage liver disease. ALD and NAFLD seem to share many pathophysiologic mechanisms with the accumulation of lipids in the liver being the first step in the development of both conditions. While mitochondrial dysf...
متن کاملNoninvasive evaluation of nonalcoholic steatohepatitis (NASH).
Sir Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of conditions, ranging from a simple fatty liver to non-alcoholic steatohepatitis (NASH) with or without fibrosis, to cirrhosis and its complications (1). It is important to distinguish NASH from simple fatty liver because NASH patients are in greater risk of developing cirrhosis, liver failure and hepatocellular carcinom...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2009
ISSN: 0270-9139
DOI: 10.1002/hep.23433